Michael Arad Selected Research

Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome)

1/2018	CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities.
10/2007	[AMP-activated protein kinase: how a mistake in energy gauge causes glycogen storage].
6/2003	Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
2/2002	Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.

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Michael Arad Research Topics

Disease

16	Cardiomyopathies (Cardiomyopathy) 01/2022 - 06/2003
14	Heart Failure 01/2021 - 06/2005
14	Polymorphic catecholergic ventricular tachycardia 01/2020 - 07/2007
9	Hypertrophy 01/2021 - 06/2003
8	Cardiac Arrhythmias (Arrythmia) 01/2021 - 07/2007
8	Cardiomegaly (Heart Hypertrophy) 01/2021 - 02/2002
8	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2019 - 02/2002
6	Fibrosis (Cirrhosis) 06/2022 - 02/2002
6	Diabetic Cardiomyopathies 10/2020 - 01/2017
6	Inflammation (Inflammations) 12/2018 - 01/2015
5	Obesity 01/2021 - 01/2016
5	Glycogen Storage Disease Type IIb 09/2017 - 06/2003
5	Ischemia 01/2016 - 04/2005
4	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2021 - 07/2014
4	Neoplasms (Cancer) 01/2021 - 03/2007
4	Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome) 01/2018 - 02/2002
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2016
3	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2021 - 01/2019
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021 - 01/2018
3	Ventricular Tachycardia 01/2019 - 12/2013
3	Insulin Resistance 08/2017 - 01/2016
3	Left Ventricular Dysfunction 01/2015 - 03/2009
2	Heart Diseases (Heart Disease) 07/2021 - 01/2018
2	Amyloidosis 01/2021 - 01/2021
2	Mitochondrial Diseases (Mitochondrial Disease) 05/2019 - 01/2018
2	Fabry Disease (Fabry's Disease) 01/2019 - 01/2018
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2019 - 12/2013
2	Sudden Death 01/2017 - 03/2009
2	Protein Deficiency 01/2017 - 12/2012
2	Reperfusion Injury 07/2011 - 04/2008
2	Hypoxia (Hypoxemia) 07/2011 - 03/2007
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2005 - 06/2003
2	Atrioventricular Block 09/2003 - 02/2002
2	Glycogen Storage Disease (Glycogenosis) 06/2003 - 02/2002
1	Fatty Liver 06/2022
1	Muscular Dystrophies (Muscular Dystrophy) 01/2022
1	Aortic Valve Stenosis (Aortic Stenosis) 09/2021
1	Aortic Dissection 07/2021
1	Pathologic Dilatation (Ectasia) 07/2021
1	Marfan Syndrome (Marfan's Syndrome) 07/2021
1	Muscular Diseases (Myopathy) 01/2021
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2021
1	Hyponatremia 10/2020
1	Primary Graft Dysfunction 01/2020

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
9	CalsequestrinIBA 01/2020 - 07/2007
8	GlycogenIBA 01/2018 - 06/2003
7	CalciumIBA 01/2021 - 01/2009
7	AMP-Activated Protein KinasesIBA 10/2007 - 02/2002
6	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 08/2015 - 07/2007
4	DystrophinIBA 01/2021 - 01/2018
4	CatecholaminesIBA 01/2021 - 11/2010
4	Sirtuin 1IBA 05/2019 - 01/2018
4	Phosphotransferases (Kinase)IBA 01/2018 - 03/2007
3	AcidsIBA 10/2020 - 01/2016
3	PPAR gammaIBA 10/2020 - 12/2018
3	Angiotensin IIIBA 05/2019 - 01/2018
3	LeptinIBA 12/2018 - 10/2007
3	ConnectinIBA 01/2018 - 06/2012
2	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 01/2018
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 01/2021
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2021 - 08/2014
2	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 10/2020 - 01/2016
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 10/2020 - 08/2017
2	Adenosine Monophosphate (AMP)IBA 01/2018 - 03/2007
2	AngiotensinsIBA 01/2018 - 01/2017
2	Lysosomal Membrane ProteinsIBA 09/2017 - 03/2009
2	RyanodineIBA 08/2015 - 12/2012
2	Pharmaceutical PreparationsIBA 08/2014 - 01/2010
2	Propranolol (Inderal)FDA LinkGeneric 08/2014 - 11/2010
2	Epinephrine (Adrenaline)FDA LinkGeneric 08/2014 - 12/2013
2	Verapamil (Calan)FDA LinkGeneric 03/2011 - 11/2010
2	Procainamide (Procan)FDA LinkGeneric 11/2010 - 09/2003
2	Adenosine (Adenocard)FDA LinkGeneric 01/2010 - 09/2003
1	Ion Channels (Ion Channel)IBA 01/2022
1	Lamin Type A (Lamin A)IBA 07/2021
1	Anesthetics (Anesthetic Agents)IBA 07/2021
1	Antihypertensive Agents (Antihypertensives)IBA 01/2021
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2021
1	omega-Chloroacetophenone (Mace)IBA 01/2021
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	FilaminsIBA 10/2020
1	OxygenasesIBA 10/2020
1	AntioxidantsIBA 10/2020
1	Digoxin (Digitek)FDA LinkGeneric 10/2020
1	Prostaglandins DIBA 01/2020
1	Thyroid HormonesIBA 01/2020
1	tin mesoporphyrinIBA 05/2019
1	SirtuinsIBA 05/2019
1	cobaltiprotoporphyrinIBA 05/2019

Therapy/Procedure

16	Therapeutics 01/2021 - 09/2003
5	Heart Transplantation (Grafting, Heart) 01/2020 - 03/2009
4	Caloric Restriction 05/2019 - 01/2017
2	Exercise Therapy (Therapy, Exercise) 11/2019 - 01/2017
2	Enzyme Replacement Therapy 01/2019 - 11/2015
2	Peritoneal Dialysis 01/2015 - 01/2013
1	Transcatheter Aortic Valve Replacement 09/2021
1	Anesthesia 07/2021
1	Pain Management 07/2021